Company Overview
Knock Knock Games was an “instant games” game studio producing HTML5-based games that could be played instantly on chat platforms like Facebook Instant Games and WeChat. It produced numerous 2D and 3D titles with its greatest hit being “Car Match: Hollywood”, a match game which garnered millions of installs.
Role Overview
As Senior Research Scientist at Acme Laboratories, I lead a dynamic team investigating bacterial resistance mechanisms with the goal of developing next-generation antimicrobial therapies.
Key Achievements
- Grant Success: Secured competitive NIH R01 grant ($250,000) to fund multi-year study on novel resistance pathways
- Publication Record: First-author on 2 papers in Nature Microbiology and Cell Host & Microbe
- Team Leadership: Built and mentored high-performing research team, resulting in 40% increase in lab productivity
Research Focus
My work centers on understanding how bacteria evolve resistance to last-resort antibiotics. Using advanced genomic techniques and high-throughput screening, we’ve identified several promising therapeutic targets.
Key techniques and methods:
- CRISPR-based genetic manipulation
- Whole-genome sequencing and bioinformatics analysis
- High-content imaging and automated microscopy
- Protein crystallography and structural biology
Collaborative Projects
Working closely with the medicinal chemistry team to translate our findings into drug candidates. Also partnered with Stanford University researchers on a cross-institutional study of hospital-acquired infections.
Impact
Our research has informed clinical guidelines for antibiotic stewardship and contributed to the development pipeline for two novel antimicrobial compounds currently in preclinical testing.